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KMID : 1134820190480050533
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Journal of the Korean Society of Food Science and Nutrition
2019 Volume.48 No. 5 p.533 ~ p.541
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Cardioprotective Effects of Cold-Water Treated Wheat Flour on Ischemia/Reperfusion-Induced Myocardial Injury in Rats
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Lim Sun-Ha
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Abstract
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A previous study reported that supplementation with hot-water extracted wheat (WE) reduces myocardial injury in a myocardial infarction model. On the other hand, the production of WE on a large scale results in the gelatinization of starch, which has made the production of WE difficult. To solve this problem, cold-water treated wheat flour (CWWF) was prepared to release water-soluble arabinoxylan, an active component in wheat, into the water, and this study investigated whether CWWF could show the same cardioprotective efficacy as WE. To prepare CWWF, wheat flour at various ratios of water (wheat flour:cold-water＝1:2, 1:3, or 1:5) was stirred at room temperature for one hour and then freeze-dried. The rats were supplemented with these CWWFs at a dose of 500 mg/kg/d for 3 days, and subjected to ischemia (30 min)/reperfusion (3 h) through ligation and release of the left anterior descending coronary artery. The cardioprotective effects of CWWF on the rats that had been treated with CWWFs at 1:3 and 1:5 ratios were statistically significant, in which CWWF at a 1:5 (1:5 CWWF) ratio was more effective. When the rats were fed 1:5 CWWF at various doses, a cardioprotective effect was observed at doses of more than 200 mg/kg/d. The cardioprotective effects of 1:5 CWWF were attributed to the inhibition of the apoptotic cascade through the increased ratio of Bcl-2/Bax protein, and decreased generation of nicked DNA. These results suggest that CWWF intake can reduce myocardial infarction by inhibiting apoptosis.
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KEYWORD
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wheat flour, cold-water extract, arabinoxylan, myocardial infarction, apoptosis
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